Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Two of these loci map to genes (TCF7L2 and TGFB1) with established roles in colorectal tumorigenesis.
|
24836286 |
2014 |
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
To further understand the roles played by differential expression and splicing isoforms of human Tcf-4 in brain tumorigenesis, the expression of the 3' part of the Tcf-4 gene (exons 10-17) was analyzed by RT-PCR, nested RT-PCR and DNA sequencing.
|
15547706 |
2004 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Thus, loss of the TCF-4 capacity to interact with COOH-terminal binding protein could be an important event during colorectal carcinogenesis by modifying Wnt signaling.
|
10919662 |
2000 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that telomerase and ILK activation occurs during the later stages of carcinoma progression, whereas upregulation of survivin, c-MYB, and Tcf-4 is a feature of the early stage of development of neoplasia, and thus, they might serve as early indicators for UC-associated colorectal carcinogenesis.
|
20027603 |
2010 |
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These results suggest that TCF-4 frameshift mutations are selected for and play a role in colorectal MSI-H tumorigenesis.
|
10485457 |
1999 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The function of beta-catenin as a transcriptional coactivator of T-cell factor-4 (TCF-4) is crucial for colorectal carcinogenesis.
|
18439914 |
2008 |
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Subsequently, accumulated beta-catenin protein translocates to nuclei with T-cell factor-4, and upregulates transcriptional activity of the target genes involved in carcinogenesis.
|
11696170 |
2001 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Pleiotropic function of SRY-related HMG box transcription factor 4 in regulation of tumorigenesis.
|
23080209 |
2013 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our results, taken together with the recent findings that c-myc transcription is negatively regulated by APC and our earlier data on transcriptional activation of eIF-4E expression by c-Myc suggest that eIF-4E is a downstream target of the APC/beta-catenin/Tcf-4 pathway, and is strongly involved in colon tumorigenesis.
|
10229202 |
1999 |
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
It was found that mutations in the TCF-4 A(9) repeat do not contribute to tumorigenesis and seem to be passenger mutations.
|
12036905 |
2002 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
It is controversial whether Tcf4 (Tcf7L2) functions as an oncogene or tumor suppressor gene in colon carcinogenesis.
|
21383188 |
2011 |
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
It has therefore been considered that constitutive activation of TCF4 by aberrant Wnt signaling is a major force driving colorectal carcinogenesis.
|
20530691 |
2010 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis.
|
12384519 |
2002 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Here, we investigated TCF-4 isoforms (TCF-4J and K)-responsive target genes that are important in hepatic oncogenesis and tumour development.
|
23651211 |
2013 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Finally, genetic aberrations of several components of the beta-catenin pathways, eg, Frizzled (Frz), AXIN, and TCF-4, may potentially contribute to colorectal carcinogenesis.
|
11839557 |
2002 |
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Although some of the consequences associated with the accumulated β-catenin have been clarified, the comprehensive effect of activated β-catenin/TCF7L2 transcriptional complex on tumorigenesis remains to be elucidated.
|
28117551 |
2017 |
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Accumulative evidence suggests that alterations due to mutations or genetic polymorphisms in the TCF7L2 and CCND1 genes, which are components of the Wnt signaling pathway, contributes to carcinogenesis.
|
27755946 |
2016 |
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Aberrant activation of the beta-catenin/Tcf-4 transcriptional complex represents an initiating event for colorectal carcinogenesis, shifting the balance from differentiation toward proliferation in colonic crypts.
|
17920061 |
2007 |
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
TCF7L2 rs12255372 (G>T) polymorphism contributes to breast carcinogenesis: evidence from a meta-analysis.
|
24266846 |
2013 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
T cell factor-4 (TCF-4) plays an important role in development and carcinogenesis.
|
15667799 |
2005 |